Please, Sama, go back to the gym! That’s where you belong, using your muscles, not your brain.
You’ve now inspected the fatty acids attached to cholesterol inside plaques and somehow solved dietary cardiology. By the same logic, finding oxygen at a house fire proves oxygen caused the blaze. The drainpipe cartoon is crude; your replacement is merely nonsense wearing a lab coat.
The 1994 Lancet paper didn’t discover that arteries were “full of seed oil”. It examined post-mortem aortic plaques and found that their fatty-acid composition correlated with fatty acids in serum and adipose tissue. That describes what was present in established lesions. It doesn’t identify what initiated those lesions, demonstrate that the polyunsaturated fatty acids came specifically from industrial seed oils, or show that replacing butter caused atherosclerosis.
“Unsaturated fat” isn’t another name for seed oil. The category includes monounsaturated and polyunsaturated fatty acids from numerous dietary and endogenous sources. Plaques also contain free cholesterol, cholesteryl esters, phospholipids, triglycerides, cellular debris and connective tissue. The reported fatty acids were largely attached to complex plaque lipids. You took one compositional category and promoted it to a dietary culprit. So typical of you.
Your scab analogy fails at the next step. Atherosclerosis doesn’t require a torn artery that “invites” cholesterol through. ApoB-containing particles can cross intact endothelium and become retained by proteoglycans in susceptible regions of the arterial wall. They are then modified through oxidation, aggregation, lipolysis and other processes, provoking inflammation, macrophage uptake and foam-cell formation. Inflammation amplifies the lesion; it doesn’t explain away the particles retained inside it. You invented a wound because your scab metaphor needed one.
No competent account says swallowed butter floats unchanged through the bloodstream and sticks like cold grease in a drain. Saturated fat can increase circulating LDL and apoB particle burden. Greater cumulative exposure creates more opportunities for those particles to enter and remain in the arterial wall. Refuting a children’s cartoon doesn’t refute the actual mechanism.
The outcome evidence ruins your seed-oil alibi as well. Genetic variants, prospective cohorts and randomized LDL-lowering trials converge on a dose- and duration-dependent causal relationship between LDL exposure and atherosclerotic cardiovascular disease. Long-term randomized trials also find fewer cardiovascular events when saturated fat is reduced, particularly when polyunsaturated fat replaces it. Plaques containing unsaturated fatty acids don’t reverse those findings.
The pipe was always a metaphor. You responded by mistaking plaque composition for disease causation, unsaturated chemistry for industrial origin and a small post-mortem study for a controlled dietary experiment. The leaflet may have simplified cardiology. You converted one paper into an elaborate seed-oil costume.
The fat in a blocked artery is three quarters unsaturated, and a cardiologist has known that since 1994.
The pipe story goes like this: you eat butter, the butter floats about in the blood, the butter sticks to the wall like grease in a drain, one day the drain is shut. It is the tidiest piece of medicine ever drawn on a napkin, and every part of it is wrong.
Dietary fat does not float about. It is packaged in the gut, shipped to your fat stores and muscle, and is gone from the blood within hours. Plaque does not sit in the pipe like sludge; it grows inside the wall, underneath the lining, where nothing you swallowed can reach it without an invitation. And the invitation is damage: a cholesterol particle gets through the lining, oxidises, and the immune system builds a scab over it. A plaque is a scab on the inside of a pipe, not a lump of dripping in the bend.
In 1994 The Lancet did the obvious thing and cut the plaques open to see what the fat inside them actually was. 26% saturated. 74% unsaturated, and more than 40% of it polyunsaturated, the fat that oxidises, the fat that comes out of a seed, the fat the butter was replaced with.
So the drain was never blocked with butter. It was scabbed over a wound, and the wound was full of the stuff the leaflets told two generations to cook with instead.
The pipe was a metaphor. The seed oil was a diet.
https://x.com/SamaHoole/status/2102844968930804007?s=20
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